Steven Watterson

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Computational Cardiovascular Research @ Ulster University

2024
Senescence Biomarkers CKAP4 and PTX3 Stratify Severe Kidney Disease Patients Cells 13(19), 1613.
Potential Plasma Proteins (LGALS9, LAMP3, PRSS8 and AGRN) as Predictors of Hospitalisation Risk in COVID-19 Patients Biomolecules 14(9) 1163.

2023
PA comparison of the Netherlands, Norway and UK familial hypercholesterolemia screening programmes with implications for target setting and the UK’s NHS long term plan PLoS Global Public Health e0001795..

2022
The Need for Standardizing Diagnosis, Treatment and Clinical Care of Cholecystitis and Biliary Colic in Gallbladder Disease Medicina Volume 58(3) 388, March 2022

2021
The Interdependency and Co-Regulation of the Vitamin D and Cholesterol Metabolism Cells 2021, 10(8), 2007
The role of senescence in the pathogenesis of atrial fibrillation - A target process for health improvement and drug development Ageing Research Reviews, Volume 69, August 2021, 101363
Deep Learning in Systems Medicine Briefings in Bioinformatics, Volume 22, Issue 2, March 2021, Pages 1543–1559
An Early Stage Researcher's Primer on Systems Medicine Terminology Network and systems medicine. 2021 Feb 1;4(1):2-50.

2020
Network and Systems Medicine - Position Paper of the European Collaboration on Science and Technology Action on Open Multiscale Systems Medicine Network and Systems Medicine 3(1), 67-90 (2020)
Opportunities for multiscale computational modelling of serotonergic drug effects in Alzheimer's disease Neuropharmacology 174, 108118 (2020)

2019
An exploratory analysis investigating blood protein biomarkers to augment ECG diagnosis of ACS Journal of Electrocardiology 57, S92-7 2019
New models of atherosclerosis and multi-drug therapeutic interventions Bioinformatics, Volume 35, Issue 14, Pages 2449-2457, 2019
Propionibacterium acnes and Acne Vulgaris - New Insights from the Integration of Population Genetic, Multi-Omic, Biochemical and Host-Microbe Studies Microorganisms 7(5), 128 (2019)

2018
Systems medicine disease maps - community-driven comprehensive representation of disease mechanisms npj Systems Biology and Applications, Volume 4, Article number: 21, 2018

2017
Is systems pharmacology ready to impact upon therapy development? A study on the cholesterol biosynthesis pathway British Journal of Pharmacology, Volume 174, Issue 23, Pages 4362-4382, 2017
Role of tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and associated proteins in coronary artery disease and cardiac events Archives of Cardiovascular Diseases, Volume 110, Issue 12, Pages 700-711, 2017
Coincidence versus consequence - opportunities in multi-morbidity research and inflammation as a pervasive feature Expert Review of Precision Medicine and Drug Development, Volume 2, Issue 3, page 147-156, 2017

2016
Computational modelling of atherosclerosis Briefings in Bioinformatics, Volume 17, Issue 4, Pages 562–575, 2016
The genetics and screening of familial hypercholesterolaemia Journal of Biomedical Science 23:39, 2016
An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway PLOS Biology 14(3) e1002364, 2016
Academia - Gap widens for honorary PhDs (Correspondence) Nature Volume 537, page 167, 2016

2015
Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon in primary macrophages requires endogenous 25-hydroxycholesterol synthesis Steroids Volume 99, Part B, Pages 219-229, 2015

2013
A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway Biochemical Pharmacology, Volume 86, Issue 1, Pages 56-66, 2013
A model of flux regulation in the cholesterol biosynthesis pathway - Immune mediated graduated flux reduction versus statin-like led stepped flux reduction Biochimie, Volume 95, Issue 3, Pages 613-621, 2013
The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response Immunity Volume 38, Issue 1, Pages 106-118, 2013

2012
Digital clocks - simple Boolean models can quantitatively describe circadian systems J. R. Soc. Interface Volume 9, Issue 74, Page 2365-2382, 2012

2011
Regulation and feedback of cholesterol metabolism Nature Precedings Issue 713, 2011
Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis PLoS Biology, Volume 9, Issue 3, e1000598, 2011
The in silico macrophage - toward a better understanding of inflammatory disease Genome Medicine, Volume 3, 4, 2011
Translation from the Quantified Implicit Process Flow Abstraction in SBGN-PD Diagrams to Bio-PEPA Illustrated on the Cholesterol Pathway Transactions on computational systems biology XIII, 13-38, 2011

2010
Transcriptional complex assembly represented in SBGN PD Nature Precedings 2010
Construction of a large scale integrated map of macrophage pathogen recognition and effector systems BMC Systems Biology 4:63, 2010
Use of logic theory in understanding regulatory pathway signaling in response to infection Future Microbiology 5 (2), 163-176, 2010

2009
The Systems Biology Graphical Notation Nature Biotechnology, Volume 27, Pages 735–741, 2009
Inference of transition probabilities between the attractors in Boolean networks with perturbation GENSIPS 2009. IEEE International Workshop on Genomic Signal Processing and Statistics, Pages 1-4, 2009.

2008
Logic Models of Pathway Biology Drug Discovery Today, Volume 13, Issue 9/10, Pages 447–456, 2008

2007
THE CHIRAL AND FLAVOR PROJECTION OF DIRAC–KÄHLER FERMIONS IN THE GEOMETRIC DISCRETIZATION International Journal of Geometric Methods in Modern Physics, Volume 05, No 03, Pages 1-18, 2007
The flavour projection of staggered fermions and the quarter-root trick Journal of High Energy Physics (JHEP), 06(2007) 048, 2007